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Approach and Outputs of H4DC

The H4DC project is structured by 3 differents aspects with their own outputs.

ASPECT N°1

Detect and Limit parasite dissemination in farms.

One of the unique features of H4DC project stands in the co-development methodology with farmers (at least 10 to 15 per country: NL, BE, FR, UK). They will be integrated, from the onset, in the thought process to develop pilot farms, which are suited to the actual situation in fields and set them up across the 2 seas area. It will help to find the most adapted solution to reduce spreading risks of Cryptosporidium. Furthermore, these pilot farms will allow to define health and financial benefits of the solutions found. In parallel, searchers will create a low-cost and easy-to-use pilot in-situ parasite detection system, which can be used by farmers as well and produced by biotech companies.

photo H4DC output 1

OUTPUT N°1

-50% of parasites excreted in environment 

Decrease diarrheic calve mortality rate from 14% to 5% 

An economic benefit ranging from 7,7 to 78 million €/year 

-50% of contaminated

animals

OUTPUT N°2

Having a detection kit targeting sensitivity and specificity of 100% 

Reduce the number of false negative/positive results to less than 1% 

Raise of the TRL (Technology Readiness Level)

from 4 to 7 

Increase the use frequency of Cryptosporidium detection test in farms 

ASPECT N°2

DEVELOP TOOLS TO FIND QUICKLY DRUGS AGAINST CRYPTOSPORIDIOSIS 

CryptoDICsizeRecadréAvecFluo pour site

Copyright- Jérôme Follet

Nowadays, no efficient drugs exist to struggle against Cryptosporidium as there are no tools to detect automatically the molecules activities against the parasite. However, searchers involved in H4DC (YNCREA/CNRS/IEMN) have developed an electronic microsystem able to measure the electric answer from cells infected by Cryptosporidium. The goal of H4DC is to adapt this electronic Cryptosporidium-viability monitoring micro-system, applicable as standard to pharmaceutical laboratories to characterize rapidly potential therapeutic compounds. 

OUTPUT N°3

Multiply the number of analyses conducted per day (from dozen to hundreds per day) 

Reduce the time

required to obtain results 

from 72h to 24h  

Reduce the overall

costs to develop

new drugs 

Being able to test more than 1200 compounds from a library of FDA-approved drugs 

ASPECT N°3

GUARANTEE THE TECHNOLOGY TRANSFER OF THE DEVELOPED TOOLS IN THE FUTURE

It is essential to adapt from the conception, the developed tools to existing demands of the main market’s actors (biotechnology and pharmaceutical companies). Consequently, H4DC’s partners will manage a market study of detection tools linked to business model and strategies to transfer technologies to the end users. Results of H4DC’s project will be disseminated by business trades or scientific conferences.

market study

OUTPUT N°4

Accelerate transfer to companies

of H4DC’s outputs in the 3 years 

(or under) following the end of the project

See the current achievements